In both writing and photography, how you use your setting can affect the image you’re trying to portray.
As you can see from these pictures of Alcatraz, I took the photos from different angles and at different times of the day. The different perspectives affect the mood of the scene.
With your novel, if there’s one setting where your story consistently takes place, see if there’s a detail or description you can incorporate that reflects the change in your main character or shows a change in time. For example, if a number of scenes occur in the hallway of the high school your character attends—and you aren’t willing to change the location—maybe show in one scene how the hallway is decorated for Valentine’s Day. Perfect if you have romance (or anti-romance) in your story.
(All these photos were taken with my point & shoot camera.)